l-Ornithine-induced inactivation of mammalian ornithine decarboxylase in vitro
نویسندگان
چکیده
منابع مشابه
Regulation of mammalian ornithine decarboxylase.
17 Melvin, M. A. L. and Keir, H. M. (1978) Expt. Cell Res. 111,231-236 18 Melvin, M. A. L. and Keir, H. M. (1979) Biochem. SOC. Trans. 7, 689-691 19 Wallace, H. M. and Keir, H. M. (1981) Biochim. Biophys. Acta 676,25-30 20 Melvin, M. A. L., Wallace, H. M. and Keir, H. M. (1980) Physiol. Chem. Phys. 12, 431-439 21 Coleman, C. S. and Wallace, H. M. (1990) 'Biochem. SOC. Trans. 18, 1228-1229 22 Wa...
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Rat antizyme gene expression requires programmed, ribosomal frameshifting. A novel autoregulatory mechanism enables modulation of frameshifting according to the cellular concentration of polyamines. Antizyme binds to, and destabilizes, ornithine decarboxylase, a key enzyme in polyamine synthesis. Rapid degradation ensues, thus completing a regulatory circuit. In vitro experiments with a fusion ...
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The inhibition of renal ornithine decarboxylase (ODC) by aminoglycoside antibiotics was characterized in the postmitochondrial fraction of a kidney homogenate from adult pigmented guinea pigs. Enzymatic activity was defined as the rate of decarboxylation of [14C]ornithine sensitive to a specific ODC inhibitor, alpha-difluoromethylornithine (DFMO). The Km for ornithine was 61 +/- 32 microM. Ther...
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Ornithine decarboxylase (ODC) activity of Ehrlich carcinoma cells was increased more than 36-fold after being maintained for 3.5 hr in vitro in a special chamber which allowed continuous perifusion with 0.5 mM ornithine; if incubated in vitro without perifusion the ODC activity was, of course, only 9-fold by the same concentration of ornithine. Ornithine withdrawal from the perifusion medium re...
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ژورنال
عنوان ژورنال: European Journal of Biochemistry
سال: 1987
ISSN: 0014-2956,1432-1033
DOI: 10.1111/j.1432-1033.1987.tb13481.x